Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY19 Administrative Supplement (Admin Supp Clinical Trial Optional) | PA 19 205

Opportunity Information: Apply for PA 19 205

This NIH opportunity (PA-19-205) is an Office of Research on Women's Health (ORWH) administrative supplement program designed to add a one-year, targeted research expansion onto an already active NIH parent grant. The central aim is to strengthen and accelerate research on the health of women from populations in the United States that are understudied, underrepresented, and underreported (often referred to as U3 populations) in biomedical research. Rather than funding an entirely new standalone project, ORWH is offering supplement dollars so existing NIH-funded teams can incorporate new aims, analyses, recruitment, or methods that directly address health disparities affecting women and that explicitly consider sex and gender influences.

The scientific focus is on how sex and gender interact with social determinants of health to shape human health and illness. ORWH highlights social determinants such as race and ethnicity, socioeconomic status, education, health literacy, and related structural or contextual factors. The supplement work can span the full research pipeline, including preclinical, clinical, behavioral, and translational research. Clinical trials are optional, meaning applicants can propose a clinical trial component if it fits the parent award and the scientific question, but it is not required.

Applications must align with the Trans-NIH Strategic Plan for Women's Health Research, "Advancing Science for the Health of Women," specifically Goals 1 and 2. In practical terms, this means proposals should either (1) advance rigorous, high-quality research that is directly relevant to women's health, or (2) develop and apply methods, approaches, or data resources that better account for sex and gender influences and thereby improve women's health research. The opportunity is particularly geared toward studies that do not treat sex or gender as an afterthought, but instead build them into the design, measurement strategy, analysis plan, and interpretation, especially where social determinants and lived context may change risks, outcomes, access to care, or responses to interventions.

A required element is that the proposed supplement project focuses on one or more NIH-designated health disparity populations. These include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities (SGM). ORWH explicitly encourages intersectional approaches that combine populations or identities, such as socioeconomically disadvantaged SGM women, because those intersections often reflect real-world patterns of unequal exposure, access, and outcomes that can be missed when populations are studied in isolation.

Eligibility is broad across common NIH-eligible applicant types, including state, county, city, and special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other eligible entities. ORWH also calls out additional eligible institutional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Despite listing "non-domestic entities" in some places, the notice clearly states that foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed, keeping the work fully domestic in scope and implementation.

Key funding details include an award ceiling of $140,000 for the supplement and an original closing date of April 8, 2019, indicating this was a time-limited FY19 supplement call. The funding instrument is a grant, categorized under discretionary funding, and it is associated with multiple CFDA program numbers across NIH. Overall, the opportunity is best understood as a mechanism for leveraging ongoing NIH-funded projects to produce near-term, concrete advances in women's health equity, especially where sex and gender influences intersect with structural and social drivers of health disparities in U.S. populations that have historically been missing from biomedical evidence bases.

• The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY19 Administrative Supplement (Admin Supp Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.313, 93.361, 93.399, 93.837, 93.838, 93.839, 93.840, 93.847, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879.
• This funding opportunity was created on 2019-03-01.
• Applicants must submit their applications by 2019-04-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $140,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 19 205

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