Opportunity Information: Apply for PAR 23 078
The Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed) funding opportunity (PAR 23 078) from the National Institutes of Health supports the operation and continued development of biomedical knowledgebases whose main job is to gather and maintain high-value scientific information connected to core datasets. The emphasis is on knowledgebases that actively extract, accumulate, organize, annotate, and link expanding bodies of biomedical data so that researchers and the broader community can more easily find, interpret, and reuse that information. In practice, NIH is looking for resources that serve as authoritative hubs around particular data types or domains, where curated content is continuously updated, cross-referenced, and structured in a way that makes it more useful than scattered or unconnected datasets.
A central requirement of this announcement is strong, scalable data curation. Projects are expected to show that their curation approach is efficient, effective, and able to grow with community needs as data volume and complexity increase. That includes using semi-automated methods where appropriate, such as workflows that combine expert review with automation for tasks like entity recognition, data normalization, quality checks, ontology-based annotation, literature triage, or link generation across related resources. The goal is not simply to store information, but to keep it accurate, consistent, and meaningfully connected over time, while avoiding curation bottlenecks that make the knowledgebase unsustainable.
Software and tool development can be part of an application, but only to the extent that it is essential to running the knowledgebase or clearly improves operational efficiency. NIH draws a clear boundary here: proposals that primarily focus on building new software tools, platforms, or major standalone technology products are considered out of scope for this mechanism. Tooling should be justified as enabling core knowledgebase functions (for example, improving curation throughput, enhancing search and retrieval, strengthening interoperability, or supporting community access), rather than being the main scientific or technical aim of the project.
The award mechanism is a U24 cooperative agreement, which typically means NIH expects substantial programmatic involvement during the project period, such as coordination on milestones, governance, sharing practices, or alignment with broader NIH data ecosystem priorities. Clinical trials are not allowed under this opportunity, reinforcing that the work is centered on data/knowledge organization and community-facing resource development rather than interventional human studies.
Eligibility is broad and includes many types of organizations: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than higher education institutions); for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-U.S. (foreign) entities, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. This wide eligibility reflects NIH interest in supporting knowledgebases that serve diverse scientific communities and draw on varied institutional strengths.
From the source details provided, the opportunity is categorized as discretionary funding and uses a cooperative agreement instrument, with activity categories spanning education, environment, and health. Multiple CFDA numbers are associated with the program (including 93.113, 93.233, 93.273, 93.279, 93.307, 93.393 through 93.399, and 93.837 through 93.840, among others), indicating that the announcement can align with several NIH institutes/centers and mission areas. The original closing date listed is 2023-05-08, and the opportunity record shows a creation date of 2022-12-22. Award ceiling and expected awards are not specified in the provided listing, so applicants would typically need to consult the full FOA text and institute-specific guidance for budget expectations, scope fit, and review considerations.
Overall, this FOA is aimed at sustaining and strengthening biomedical knowledgebases as community infrastructure: curated, interconnected, continuously maintained resources grounded in core datasets, with scalable curation practices and only mission-critical software development, and with explicit exclusion of clinical trial activities.Apply for PAR 23 078
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.233, 93.273, 93.279, 93.307, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.859, 93.867.
- This funding opportunity was created on 2022-12-22.
- Applicants must submit their applications by 2023-05-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 23 078) also looked into and applied for these:
| Funding Opportunity |
|---|
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 004 Funding Number: RFA ES 23 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Medical Scientist Partnership Program (FM1 Clinical Trial Not Allowed) Apply for PAR 23 109 Funding Number: PAR 23 109 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) Apply for PAR 23 139 Funding Number: PAR 23 139 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 23 001 Funding Number: RFA ES 23 001 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) Apply for PAR 23 144 Funding Number: PAR 23 144 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $250,000 |
| Tobacco Regulatory Science (R01 Clinical Trial Optional) Apply for RFA OD 23 017 Funding Number: RFA OD 23 017 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 184 Funding Number: PAR 23 184 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 011 Funding Number: RFA ES 23 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 229 Funding Number: PAR 23 229 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 23 263 Funding Number: PA 23 263 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (U24 Clinical Trial Not Allowed) Apply for PAR 23 237 Funding Number: PAR 23 237 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Early-stage Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed) Apply for PAR 23 236 Funding Number: PAR 23 236 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
| Intervention Research to Improve Native American Health (R21 Clinical Trials Optional) Apply for PAR 23 299 Funding Number: PAR 23 299 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Intervention Research to Improve Native American Health (R34 Clinical Trial Optional) Apply for PAR 23 285 Funding Number: PAR 23 285 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Center for Exposome Research Coordination to Accelerate Precision Environmental Health (U24 Clinical Trial Not Allowed) Apply for RFA ES 23 010 Funding Number: RFA ES 23 010 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional) Apply for RFA NR 24 004 Funding Number: RFA NR 24 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional) Apply for PA 24 201 Funding Number: PA 24 201 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 24 188 Funding Number: PA 24 188 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 24 187 Funding Number: PA 24 187 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 24 189 Funding Number: PA 24 189 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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