Opportunity Information: Apply for PA 16 007
The grant opportunity titled Personalized Strategies to Manage Symptoms of Chronic Illness (R01) (Funding Opportunity Number PA-16-007) is a National Institutes of Health (NIH) research funding announcement that supports interdisciplinary projects aimed at reducing symptom burden and improving health-related quality of life (HRQL) for people living with chronic illnesses. The focus is on advancing practical, patient-centered science that helps explain why symptoms occur and how they can be prevented or better managed, especially through approaches that are targeted, innovative, and cost-effective.
The program is built around two main scientific goals. First, it encourages research that deepens understanding of the biological mechanisms behind symptoms associated with chronic illness. This can include investigating physiological, molecular, genetic, neurological, inflammatory, or other biological pathways that drive common and often debilitating symptoms (for example, pain, fatigue, sleep disturbance, cognitive changes, depression or anxiety, shortness of breath, or other symptom clusters). By clarifying underlying mechanisms, the initiative aims to strengthen the scientific basis for identifying who is most at risk, why symptoms persist, and which pathways might be best to target in treatment.
Second, the opportunity promotes the development and testing of interventions that prevent, manage, or reduce symptoms. The emphasis is on interventions that are both innovative and realistic to implement, meaning they should be designed with scalability, affordability, and real-world clinical or community settings in mind. Projects may involve developing personalized or stratified strategies, improving symptom monitoring and management, or testing targeted therapies and approaches that can demonstrably reduce symptom burden and improve HRQL in chronic illness populations. The overall expectation is that funded studies will help move symptom science toward more precise, tailored strategies rather than one-size-fits-all solutions.
This is an R01 mechanism, meaning it supports discrete, investigator-initiated research projects of substantial scope. The funding instrument type is a grant, and the activity category is listed under education and health, with CFDA number 93.361. The opportunity was created on October 16, 2015, and the original closing date listed is January 24, 2018, indicating the specific submission window associated with the posted version of the announcement.
Eligibility is broad and includes many types of domestic organizations and governmental entities, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations (other than small businesses); and small businesses. In addition, the announcement explicitly highlights a wide range of other eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This breadth reflects NIH interest in supporting research across diverse settings and populations, including groups that are often disproportionately affected by chronic illness and symptom burden.
In short, this opportunity is designed to push symptom management science forward by linking mechanistic discovery with practical intervention development, with the end goal of reducing the day-to-day impact of chronic illness symptoms and meaningfully improving quality of life for patients.Apply for PA 16 007
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Personalized Strategies to Manage Symptoms of Chronic Illness (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2015-10-16.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The funding opportunity is titled Personalized Strategies to Manage Symptoms of Chronic Illness (R01).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-16-007.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) research funding announcement.
What is the main purpose of this grant program?
The purpose is to support interdisciplinary research projects that reduce symptom burden and improve health-related quality of life (HRQL) for people living with chronic illnesses. The program emphasizes practical, patient-centered science that explains why symptoms occur and how they can be prevented or better managed.
What kinds of projects does this opportunity prioritize?
Projects are expected to advance targeted, innovative, and cost-effective approaches to symptom prevention and management. The opportunity highlights research that can realistically be implemented and scaled in clinical or community settings.
What are the two main scientific goals of this program?
The program is organized around two main scientific goals:
- Mechanistic research: Deepen understanding of the biological mechanisms behind symptoms associated with chronic illness.
- Intervention research: Develop and test interventions that prevent, reduce, or manage symptoms, with emphasis on real-world feasibility.
What does the program mean by “mechanisms behind symptoms”?
Mechanistic research in this program refers to studying biological pathways that may drive symptoms, such as physiological, molecular, genetic, neurological, inflammatory, or other biological processes. The aim is to strengthen the scientific basis for identifying who is at risk, why symptoms persist, and which pathways may be best to target in treatment.
Which symptoms are specifically mentioned as examples?
Examples of symptoms and symptom clusters mentioned include pain, fatigue, sleep disturbance, cognitive changes, depression or anxiety, and shortness of breath, as well as other symptom clusters.
Does the opportunity support research on symptom clusters (multiple symptoms together)?
Yes. The description references symptom clusters and lists multiple symptoms that commonly co-occur in chronic illness, indicating that research addressing multiple interconnected symptoms fits the focus.
What types of interventions are encouraged?
The opportunity encourages interventions that are innovative and also realistic to implement. This includes interventions designed for scalability, affordability, and use in real-world clinical or community settings. Projects may include personalized or stratified strategies, improved symptom monitoring and management, and targeted therapies or approaches that reduce symptom burden and improve HRQL.
What does “personalized” or “stratified” strategies mean in this announcement?
In the context provided, “personalized” or “stratified” strategies refer to moving beyond one-size-fits-all symptom management toward approaches that are tailored to individuals or subgroups, with the goal of improving outcomes by matching strategies to risk, symptom patterns, or underlying mechanisms.
What outcomes does NIH expect studies to improve?
The announcement emphasizes reducing symptom burden and improving health-related quality of life (HRQL) for people living with chronic illness.
What does “patient-centered science” mean here?
Based on the description, “patient-centered science” refers to research focused on symptoms and day-to-day impacts that matter directly to patients, aiming for practical improvements in symptom management and quality of life.
What is the funding mechanism for this opportunity?
This opportunity uses the R01 mechanism.
What does an R01 support?
An R01 supports discrete, investigator-initiated research projects of substantial scope.
What is the funding instrument type?
The funding instrument type is a grant.
What is the activity category listed for this opportunity?
The activity category is listed under education and health.
What is the CFDA number associated with this program?
The CFDA number listed is 93.361.
When was this opportunity created?
The opportunity was created on October 16, 2015.
What is the original closing date shown in the announcement?
The original closing date listed is January 24, 2018, reflecting the submission window associated with the posted version described.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include many types of domestic organizations and governmental entities, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Native American tribal governments (federally recognized)
- Tribal organizations (including those other than federally recognized tribal governments)
- Public housing authorities and Indian housing authorities
- Nonprofits (with or without 501(c)(3) status; excluding institutions of higher education when specified)
- For-profit organizations (other than small businesses)
- Small businesses
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The announcement explicitly includes non-domestic (non-U.S.) entities (foreign organizations) among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The announcement lists U.S. territories or possessions among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The opportunity explicitly includes faith-based or community-based organizations as eligible applicants.
Which types of minority-serving institutions are called out as eligible?
The announcement explicitly highlights eligibility for multiple minority-serving institution types, including:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISI)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
Are federal agencies eligible to apply?
Yes. The opportunity includes eligible federal agencies among potential applicants.
Does the announcement emphasize particular populations or settings?
It emphasizes supporting research across diverse settings and populations, including groups that are often disproportionately affected by chronic illness and symptom burden.
What is the overall expectation of funded studies?
The overall expectation is that funded studies will help move symptom science toward more precise, tailored strategies for symptom prevention and management, rather than relying on one-size-fits-all approaches.
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