Personalized Strategies to Manage Symptoms of Chronic Illness (R01) | PA 16 007

Opportunity Information: Apply for PA 16 007

The grant opportunity titled Personalized Strategies to Manage Symptoms of Chronic Illness (R01) (Funding Opportunity Number PA-16-007) is a National Institutes of Health (NIH) research funding announcement that supports interdisciplinary projects aimed at reducing symptom burden and improving health-related quality of life (HRQL) for people living with chronic illnesses. The focus is on advancing practical, patient-centered science that helps explain why symptoms occur and how they can be prevented or better managed, especially through approaches that are targeted, innovative, and cost-effective.

The program is built around two main scientific goals. First, it encourages research that deepens understanding of the biological mechanisms behind symptoms associated with chronic illness. This can include investigating physiological, molecular, genetic, neurological, inflammatory, or other biological pathways that drive common and often debilitating symptoms (for example, pain, fatigue, sleep disturbance, cognitive changes, depression or anxiety, shortness of breath, or other symptom clusters). By clarifying underlying mechanisms, the initiative aims to strengthen the scientific basis for identifying who is most at risk, why symptoms persist, and which pathways might be best to target in treatment.

Second, the opportunity promotes the development and testing of interventions that prevent, manage, or reduce symptoms. The emphasis is on interventions that are both innovative and realistic to implement, meaning they should be designed with scalability, affordability, and real-world clinical or community settings in mind. Projects may involve developing personalized or stratified strategies, improving symptom monitoring and management, or testing targeted therapies and approaches that can demonstrably reduce symptom burden and improve HRQL in chronic illness populations. The overall expectation is that funded studies will help move symptom science toward more precise, tailored strategies rather than one-size-fits-all solutions.

This is an R01 mechanism, meaning it supports discrete, investigator-initiated research projects of substantial scope. The funding instrument type is a grant, and the activity category is listed under education and health, with CFDA number 93.361. The opportunity was created on October 16, 2015, and the original closing date listed is January 24, 2018, indicating the specific submission window associated with the posted version of the announcement.

Eligibility is broad and includes many types of domestic organizations and governmental entities, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations (other than small businesses); and small businesses. In addition, the announcement explicitly highlights a wide range of other eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This breadth reflects NIH interest in supporting research across diverse settings and populations, including groups that are often disproportionately affected by chronic illness and symptom burden.

In short, this opportunity is designed to push symptom management science forward by linking mechanistic discovery with practical intervention development, with the end goal of reducing the day-to-day impact of chronic illness symptoms and meaningfully improving quality of life for patients.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Personalized Strategies to Manage Symptoms of Chronic Illness (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
• This funding opportunity was created on 2015-10-16.
• Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 16 007

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: