Opportunity Information: Apply for RFA FD 22 009
The Federal and State Integration Activities to Advance Cooperation and Regulatory Standards Among Animal Food Safety Regulatory Programs (U2F) opportunity (RFA-FD-22-009) is a Food and Drug Administration (FDA) cooperative agreement designed to strengthen the national animal food safety system by improving how federal and state partners work together. The central aim is long-term, system-level improvement: tighter interagency coordination, stronger state regulatory and surveillance programs for animal foods (including pet food), and broader education, outreach, and promotion of the Animal Feed Regulatory Program Standards (AFRPS). Clinical trials are not allowed under this funding, reflecting that the work is focused on regulatory capacity, integration, and prevention-based public health practice rather than clinical research.
The program is rooted in the FDA Food Safety Modernization Act (FSMA), which expanded FDA's public health mandate beyond reacting to contamination events and toward preventing them. FSMA applies to both human and animal food, and it directed FDA to establish modern preventive safety standards across the supply chain, including growers, processors, transporters, and storage operators. A key premise of the opportunity is that FDA cannot meet FSMA's prevention and risk-based goals alone because food safety oversight in the United States is shared across a very large network of agencies. Congress specifically recognized the role of more than 3,000 state, local, territorial, and tribal agencies involved in food safety, including animal food safety, and emphasized that these partners must be fully integrated with FDA efforts. In practical terms, the grant supports activities that make federal-state work more consistent and interoperable, so animal food oversight operates as one coordinated system rather than disconnected programs.
The funded work is expected to help align regulatory approaches and build consistent program capabilities across jurisdictions, improving the quality, consistency, and effectiveness of enforcement, monitoring, and preventive controls that protect the animal food supply. This includes efforts to enhance state surveillance and protection programs for animal foods and to expand understanding and adoption of the AFRPS, which are standards intended to help state feed regulatory programs develop and demonstrate a strong, reliable foundation for oversight. Education and outreach components are explicitly highlighted, signaling that the program values not only internal regulatory improvements but also communication and promotion strategies that increase awareness, encourage participation, and support uniform implementation of best practices.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning the FDA is expected to have substantial involvement with the recipient during the project period rather than acting solely as a pass-through funder. The activity category aligns with agriculture, consumer protection, and food and nutrition, and the program is listed under CFDA 93.103. Eligible applicants are limited to nonprofit organizations, including 501(c)(3) nonprofits and other nonprofit entities that are not institutions of higher education. The opportunity was posted by the Department of Health and Human Services (HHS), FDA, with a creation date of January 26, 2022, and an original application closing date of April 4, 2022. The award ceiling is $350,000, and FDA anticipated making one award, indicating a single, focused project intended to have broad integration impact rather than multiple smaller awards spread across different applicants.Apply for RFA FD 22 009
- The Department of Health and Human Services, Food and Drug Administration in the agriculture, consumer protection, food and nutrition sector is offering a public funding opportunity titled "Federal and State Integration Activities to Advance Cooperation and Regulatory Standards Among Animal Food Safety Regulatory Programs (U2F) Clinical Trials Not Allowed" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.103.
- This funding opportunity was created on Jan 26, 2022.
- Applicants must submit their applications by Apr 04, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
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| Revision Applications - Manufactured Food Flexible Funding Model Compliance and Enforcement Expansion Supplement (U18) (Clinical Trials Not Allowed) Apply for RFA FD 22 019 Funding Number: RFA FD 22 019 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $100,000 |
| Retail Food Safety Regulatory Association Collaboration (U18) (Clinical Trial Not Allowed) Apply for RFA FD 22 008 Funding Number: RFA FD 22 008 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Renewal - Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 22 025 Funding Number: RFA FD 22 025 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| Renewal- Local Food Producer Outreach, Education, and Training to Enhance Food Safety and FDA Food Safety Modernization Act (FSMA) Compliance (U01) Clinical Trail Not Allowed Apply for RFA FD 22 024 Funding Number: RFA FD 22 024 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Funding Opportunity Title Innovation Award: Minority Health and Health Equity (U01) Clinical Trials Optional Apply for RFA FD 22 005 Funding Number: RFA FD 22 005 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| OMHHE Educational Funding Opportunity: Expanding education on skin lightening products (U01) Clinical Trials Optional Apply for RFA FD 22 020 Funding Number: RFA FD 22 020 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $250,000 |
| Building Research Capacity in Global Tobacco Product Regulation Program (U18) Clinical Trials Not Allowed Apply for RFA FD 23 003 Funding Number: RFA FD 23 003 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $400,000 |
| Cooperative Agreement to Support the Food and Agriculture Organization (FAO) (U01) Clinical Trials Not Allowed Apply for RFA FD 23 020 Funding Number: RFA FD 23 020 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $750,000 |
| Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed Apply for RFA FD 23 027 Funding Number: RFA FD 23 027 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $565,000 |
| Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Clinical Trials Not Allowed Apply for RFA FD 23 019 Funding Number: RFA FD 23 019 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $360,000 |
| Renewal-Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 23 032 Funding Number: RFA FD 23 032 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $500,000 |
| Renewal-Local Food Producer Outreach, Education and Training to Enhance Food Safety and FDA Food Safety Modernization Act (FSMA) Compliance (U01) Clinical Trial Not Allowed Apply for RFA FD 23 031 Funding Number: RFA FD 23 031 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $1,000,000 |
| Vet-LIRN Capacity-Building Project and Equipment Grants (U18) Apply for PAR 23 202 Funding Number: PAR 23 202 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,500,000 |
| Cooperative Agreement to Support an Evidence-Based Clinical Practice Guideline for the Management of Laparoscopic Abdominal Surgeries (U01) Clinical Trials Not Allowed Apply for RFA FD 23 035 Funding Number: RFA FD 23 035 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,000,000 |
| Cooperative Agreement to Support an Evidence-Based Clinical Practice Guideline for the Management of Acute Low Back Pain (U01) Clinical Trials Not Allowed Apply for RFA FD 23 034 Funding Number: RFA FD 23 034 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $2,000,000 |
| Data Standards for Tobacco Research and Scientific Review Phase 2 Apply for RFA FD 24 001 Funding Number: RFA FD 24 001 Agency: Department of Health and Human Services, Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $250,000 |
| Manufacturing Sector Research Initiative Apply for RFA FD 17 009 Funding Number: RFA FD 17 009 Agency: Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $35,000,000 |
| Cooperative Agreement to Support the Joint Institute for Food Safety and Applied Nutrition, JIFSAN (U19) Apply for RFA FD 17 003 Funding Number: RFA FD 17 003 Agency: Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $3,300,000 |
| National Laboratory Curriculum Framework Development Apply for RFA FD 17 012 Funding Number: RFA FD 17 012 Agency: Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $3,750,000 |
| Developing Biomarkers for Trastuzumab-induced Cardiotoxicity Apply for RFA FD 17 006 Funding Number: RFA FD 17 006 Agency: Food and Drug Administration Category: Agriculture, Consumer Protection, Food and Nutrition Funding Amount: $140,000 |
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