Advancing Genomic Medicine Research (R01 Clinical Trial Optional) | RFA HG 25 002

Opportunity Information: Apply for RFA HG 25 002

The Advancing Genomic Medicine Research (R01 Clinical Trial Optional) opportunity (RFA HG 25 002) is a discretionary National Institutes of Health grant sponsored by the National Human Genome Research Institute (NHGRI). It is designed to support R01-level research that pushes genomic medicine forward in real-world clinical care, with a strong emphasis on practical implementation: figuring out when genomic information should be used, where it fits into different care settings, and how to use and share genomic results and related technologies in ways that actually improve healthcare delivery. The NOFO explicitly centers all people, with particular attention to populations and communities that experience health disparities, including racial or ethnic minority groups, people with lower socioeconomic status, underserved rural communities, and sexual and gender minority groups. Clinical trials are optional, meaning applicants can propose either trial or non-trial research depending on what best fits the scientific and implementation goals.

At its core, the program is aimed at generating evidence and innovations that make genomic medicine more effective, more usable, and more equitable in routine practice. That includes studying how genomic data are integrated into clinical workflows, how results are communicated and acted on by clinicians and patients, and how health systems can responsibly share genomic information while addressing barriers such as access, trust, privacy, and infrastructure limitations. The focus on “use and sharing” signals interest not just in generating genomic data, but in the policies, tools, processes, and models that allow genomic knowledge to move safely and meaningfully between laboratories, clinicians, patients, and health systems. Projects aligned with this goal often involve implementation science approaches, evaluation of real-world uptake and outcomes, strategies to reduce disparities in access and benefit, and methods to ensure genomic applications are appropriate across diverse populations and settings.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants listed for this opportunity include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other applicant types as permitted by NIH policy. The announcement also calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This wide eligibility reflects the program’s interest in reaching health systems, community partners, and institutions that are well positioned to address gaps in genomic medicine implementation and equity.

Restrictions related to foreign participation are clearly stated. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” as defined by the NIH Grants Policy Statement are allowed, which typically means a U.S. applicant can include certain well-justified international elements of a project when they are necessary for the science, consistent with NIH rules and approvals.

Administrative details included in the source information indicate the opportunity is categorized under Education and Health and is associated with CFDA numbers 93.172 and 93.393. The original closing date is listed as 2025-02-11, and the record creation date is 2024-11-19. The award ceiling and expected number of awards are not specified in the provided data, so applicants would need to consult the full NOFO for budget limits, funding levels, project periods, review criteria, and any special requirements. Overall, the opportunity targets rigorous, actionable research that helps genomic medicine move from promising technology to consistent, fair, and effective clinical practice, especially in communities that have historically been left out of genomic advances.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advancing Genomic Medicine Research (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.393.
• This funding opportunity was created on 2024-11-19.
• Applicants must submit their applications by 2025-02-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HG 25 002

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